We currently have a single term for ganglion mother cell (GMC, FBbt:00005149), which refers to both:
a GMC that is born directly from a type I neuroblast (FBbt:00100532),
a GMC that is born indirectly from a type II neuroblast (FBbt:00100533), through an intermediate neural progenitor (INP, FBbt:00100738).
Marques et al., 2023 (FBrf0256708), in a scRNAseq assay of 3rd instar larval neural lineages, show that GMCs from a type I neuroblast are transcriptionally distinct from GMCs from a type II neuroblast, leading them to call those cells “type I GMC“ and “type II GMC“, respectively. Type II GMCs are distinguished notably by the expression of Sp1 (FBgn0020378).
Thus I propose to create two new sub-terms to our existing ganglion mother cell:
type I ganglion mother cell: “a ganglion mother cell born from a type I neuroblast” (EquivalentTo: 'ganglion mother cell' and (develops_from some 'type I neuroblast');
type II ganglion mother cell: “a ganglion mother cell born indirectly from a type II neuroblast” (EquivalentTo: 'ganglion mother cell' and (develops_from 'type II neuroblast').
We currently have a single term for
ganglion mother cell(GMC, FBbt:00005149), which refers to both:Marques et al., 2023 (FBrf0256708), in a scRNAseq assay of 3rd instar larval neural lineages, show that GMCs from a type I neuroblast are transcriptionally distinct from GMCs from a type II neuroblast, leading them to call those cells “type I GMC“ and “type II GMC“, respectively. Type II GMCs are distinguished notably by the expression of Sp1 (FBgn0020378).
Thus I propose to create two new sub-terms to our existing
ganglion mother cell:type I ganglion mother cell: “a ganglion mother cell born from a type I neuroblast” (EquivalentTo: 'ganglion mother cell' and (develops_from some 'type I neuroblast');type II ganglion mother cell: “a ganglion mother cell born indirectly from a type II neuroblast” (EquivalentTo: 'ganglion mother cell' and (develops_from 'type II neuroblast').