For 'GSD' constructs in FBrf0245398 (PMID:32105778).
[Term]
id: FBcv:NEW
name: conditional RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005078 ! RNA-guided nuclease
[Term]
id: FBcv:NEW
name: small molecule-regulated RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:NEW ! conditional RNA-guided nuclease
For 'GSD' constructs in FBrf0245398 (PMID:32105778).
[Term] id: FBcv:NEW name: conditional RNA-guided nuclease namespace: experimental_tool_descriptor def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated in response to a particular stimulus." [FBC:GM] is_a: FBcv:0005078 ! RNA-guided nuclease
[Term] id: FBcv:NEW name: small molecule-regulated RNA-guided nuclease namespace: experimental_tool_descriptor def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM] is_a: FBcv:NEW ! conditional RNA-guided nuclease