For RDX constructs in FBrf0245398 (PMID:32105778).
new terms in tree:
split system component
split genome engineering tool
split nuclease
split RNA-guided nuclease
conditional split RNA-guided nuclease
small molecule-regulated split RNA-guided nuclease
This request uses the new split genome engineering tool term requested in #240
new term details:
[Term]
id: FBcv:NEW
name: split nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a nuclease. A functional nuclease can be reconstituted when complementary split nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:NEW ! split genome engineering tool
[Term]
id: FBcv:NEW
name: split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease. A functional RNA-guided nuclease can be reconstituted when complementary split RNA-guided nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:NEW ! split nuclease
[Term]
id: FBcv:NEW
name: conditional split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:NEW ! split RNA-guided nuclease
[Term]
id: FBcv:NEW
name: small molecule-regulated split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:NEW ! conditional split RNA-guided nuclease
For RDX constructs in FBrf0245398 (PMID:32105778).
new terms in tree:
This request uses the new
split genome engineering toolterm requested in #240new term details:
[Term] id: FBcv:NEW name: split nuclease namespace: experimental_tool_descriptor def: "Non-functional fragment of a nuclease. A functional nuclease can be reconstituted when complementary split nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM] is_a: FBcv:NEW ! split genome engineering tool
[Term] id: FBcv:NEW name: split RNA-guided nuclease namespace: experimental_tool_descriptor def: "Non-functional fragment of an RNA-guided nuclease. A functional RNA-guided nuclease can be reconstituted when complementary split RNA-guided nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM] is_a: FBcv:NEW ! split nuclease
[Term] id: FBcv:NEW name: conditional split RNA-guided nuclease namespace: experimental_tool_descriptor def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM] is_a: FBcv:NEW ! split RNA-guided nuclease
[Term] id: FBcv:NEW name: small molecule-regulated split RNA-guided nuclease namespace: experimental_tool_descriptor def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM] is_a: FBcv:NEW ! conditional split RNA-guided nuclease