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FunGeST / Palimpsest

An R package for studying mutational signatures and structural variant signatures along clonal evolution in cancer.
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Visualising the results of mutation origin #49

Open beginner984 opened 4 years ago

beginner984 commented 4 years ago

Hello

I was able to run origin function but I don't know how to visualise that or any possible plot (if already produced by function) goes where

This is the code

vcf <- signature_origins(input = vcf, Type = "SBS",
                          input_signatures = SBS_liver_sigs,
                          signature_contribution = SBS_signatures_exp)

Thanks for any help

FunGeST commented 4 years ago

Hi,

Please see section 5.6 of the package vignette and our 2017 paper for examples of how we used the origins function to study and plot the distribution of signatures in driver mutations. The code to generate these plots is in section 6 of the test script.

However, the output of the origin function is in no way limited to the study of driver mutations, thats just what we found most interesting in our liver tumours!

Benedict