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FunctionLab / sei-framework

code to run sei and obtain sei and sequence class predictions
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Why the value of seqclass_max_absdiff can greater than 2? #4

Closed LDS-axel closed 2 years ago

LDS-axel commented 2 years ago

The value of seqclass_max_absdiff, the difference between the the predicted probability of the reference allele and the alternative allele for a regulatory feature, is calculated by (palt−pref), and should have a range from 0 to 2. However, few results in Sei-framework show value greater than 2.

jzthree commented 2 years ago

The sequence class scores are not difference from two probabilities. They are projections of 21907 probabilities predicted by Sei - so that are not bounded to 0-1. Thus the abs value of the difference is not bounded by 0-1 as well.