Closed gdolsten closed 2 years ago
you can check the source code here: https://github.com/GangCaoLab/CoolBox/blob/6432254cc343ed35e4578eb2d5662cfc59ac09db/coolbox/core/track/hist/hicfeature.py#L184 it's calculated the same way as the original paper.
you can use the "normalize" parameter to get the background normalized insulation score.
For bigwig output, you can use the pybigwig package to manually create the file.
Not sure if I missed it, but which original paper are you referring to? Thanks.
This is the original paper of the IS method:
Emily Crane 2015. Condensin-driven remodelling of X chromosome topology during dosage compensation
Would it be possible to export the insulation score to a bigwig?