GenSpectrum / cov-spectrum-website

A web platform to detect and analyze variants of SARS-CoV-2
https://cov-spectrum.org
GNU General Public License v3.0
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Possibility to screen for transition/transversion ratio higher than x #647

Open focosi-cyber opened 1 year ago

focosi-cyber commented 1 year ago

As you may be aware, Ryan Hisner has identified several Omicron sequences that have unusually high transition:transversion ratios, spread along the entire genome. This is likely a hallmark of molnupiravir-induced mutagenesis. With 99.9% of GISAID sequences sampled at diagnosis as opposed to after-therapy, identifying some of such hyper mutated lineages could mean they were fit enough to spread, with important public health implications

@ryhisner @corneliusroemer @chaoran-chen @oliasdave

FedeGueli commented 1 year ago

this could be important to easily track this kind of sequences.

chaoran-chen commented 1 year ago

Thanks for this suggestion! This is a very interesting idea. I added it to our backlog - hopefully to be addressed early next year.