Possibility to screen for transition/transversion ratio higher than x

[focosi-cyber]

As you may be aware, Ryan Hisner has identified several Omicron sequences that have unusually high transition:transversion ratios, spread along the entire genome. This is likely a hallmark of molnupiravir-induced mutagenesis. With 99.9% of GISAID sequences sampled at diagnosis as opposed to after-therapy, identifying some of such hyper mutated lineages could mean they were fit enough to spread, with important public health implications

@ryhisner @corneliusroemer @chaoran-chen @oliasdave

[FedeGueli]

this could be important to easily track this kind of sequences.

[chaoran-chen]

Thanks for this suggestion! This is a very interesting idea. I added it to our backlog - hopefully to be addressed early next year.