update data to latest releases

[abearab]

21Q2 Release

Exciting Announcements

Chronos CRISPR Data This quarter, we're introducing a successor to CERES named Chronos. Chronos is based on a cell population dynamics model and provides several improvements over CERES. You can read more about the model and how we evaluated it in our preprint, as well as on this blog post. This quarter, Chronos will be available as an option for downloading or exploring in the portal. Next quarter, we plan to make it the default CRISPR dataset in the DepMap portal for gene cards and other tools.

Important Announcements

Revised Dataset Names This quarter we've standardized the nomenclature used for identifying dependency datasets in Data Explorer and other portions of the portal. Please be aware that these names have changed. For example, the dataset which was previously labeled ""CRISPR (Avana) Public 21Q1"" is now named "CRISPR (DepMap 21Q1 Public, CERES)”.

Additional Announcements

Dataset Updates

We discovered that our existing DNA sequencing data for the cell line ACH-002010 was actually from a different cell line (ACH-002011), and similarly that the DNA sequencing data for ACH-000314 was actually from ACH-000851. We have dropped the erroneous CNV and mutation data for these two lines, and plan to regenerate correct DNA-seq data.

New Downloads

Expected Gene Counts We are including expected gene counts for protein-coding and isoform data as downloadable files.

Binary Mutation Matrices We are adding the mutation binary matrix for download. This file contains the information on whether or not each gene is mutated for each cell line.

[abearab]

@Yogiski, I think it's done, so I'm closing this issue.