search

Graylab / FLAb

Fitness landscapes for antibodies
48 stars 11 forks source link

HCDR3s swapped with trastuzumab HCDR1 in Shanehsazzadeh zero-shot dataset #3

Open amirshane opened 9 months ago

amirshane commented 9 months ago

Looking at the data file in data/binding/Shanehsazzadeh2023_trastuzumab_zero_kd.csv it appears that the HCDR3 sequences from https://github.com/AbSciBio/unlocking-de-novo-antibody-design/tree/main have been copied over but in place of trastuzumab's HCDR1 instead of its HCDR3.

For example the first heavy entry is EVQLVESGGGLVQPGGSLRLSCAASTRYFFNGWYYFDVIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS

The designed HCDR3 TRYFFNGWYYFDV has been swapped for trastuzumab's HCDR1 (GFNIKDTY) and trastuzumab's HCDR3 (SRWGGDGFYAMDY) is still present.