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Graylab / FLAb

Fitness landscapes for antibodies
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Rosace et al. binding data are likely in M #4

Open edikedik opened 1 month ago

edikedik commented 1 month ago

Hi,

I believe that fitness values in the Rosace et al. binding datasets were not scaled to nM and are expressed in M.

Cheers, Ivan

julianrfaust commented 1 month ago

I find a similar issue with the units for the Warszawski 2019 binding affinity data. The D.44.1 wildtype Ab is said to be 135nM in the original paper. If the units are correct, that would make the wildtype by far the weakest binder of all the alanine mutant positions - seems pretty hard to believe. I am also curious about the Koenig 2017 data fitness units. The wildtype there is said to be 0.4 nM in the original paper so the value seems believable in the context of the ala mutants - but given the apparent incorrectness of the Warszawsi data it would be nice to confirm. Alternatively, I can go to the original papers' data to find the measurements