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Graylab / IgFold

Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies
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predict the structure using one single seq: H + linker + V #56

Closed zhendejuzi closed 11 months ago

zhendejuzi commented 1 year ago

can I use a linker (for example, GGGGGGGGGGGGG) to connect the heavy chain and the light chain, and then use igfold for structure prediction?

qiz218591 commented 11 months ago

Looking forward to the answer of the same doubt above?

jeffreyruffolo commented 11 months ago

This behavior is not technically supported, as the model is only trained on separate heavy and light chains. It might work though in some cases.