HUPO-PSI / psi-mi-CV

Molecular Interactions Controll Vocabulary
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MI:0097 (reverse ras recruitment system) relocation #276

Closed noedelta closed 8 years ago

noedelta commented 12 years ago

Shouldn't this term be moved inside MI:0230 (membrane bound complementation assay) ? Please, also note, that some of the cytoplasmic complementation assays (ie these listed within MI:0228) can be adopted to membrane proteins which makes the annotation rather confusing. On top of this cellular localization (membrane/cytoplasm; also nuclear ? some of the complementation assays, most notably Y2H, are nucleus-bound) is, conceptually, orthogonal to interaction detection and thus should be kept away from the iteraction detection terms. As far as I'm concerned, the optimal arrangement would be to get rid of MI:0230 with MI:0228 altogether, place all the child terms, together with MI:0232 (transcriptional complementation assay) branch directly within MI:0090 (protein complementation assay), and, finally, merge MI:0229 and MI:0809 into one generic term.

Reported by: lukasz99

noedelta commented 12 years ago

Cytoplasmic/membrane location terms obsoleted.

Original comment by: orchard

noedelta commented 12 years ago

Original comment by: orchard