Closed noedelta closed 8 years ago
noedelta
commented
12 years ago Could it be it's the same as : MI:0557 (adp ribosylation reaction) ? what is the final product of MI:0557 ? Definition of the term suggests both phosphate groups might be present at the modification site ?
Note: PMID: 20622875 is another paper describing this type of modification/reaction.
Original comment by: lukasz99
noedelta
commented
12 years ago Answering myself: no, these ar different so new terms are indeed needed...
Original comment by: lukasz99
noedelta
commented
12 years ago AMPylation, previously known as adenylylation, is formation of a phosphodiester or phosphoramide ester of AMP on Tyr (RESID:AA0203), Lys (RESID:AA0227), Thr (RESID:AA0267), His (RESID:AA0371) and other amino acids. ADPribosylation is the formation of a glycosyl bond with ADPribose from NAD on diphthamide (RESID:AA0040), Arg (RESID:AA0168), Cys (RESID:AA0169), Asn (RESID:AA0231), Ser (RESID:AA0237), Glu (RESID:AA0295), Lys RESID:AA0476), and others. Both processes have been known as regulatory modifications for some time, AMPylation is usually easily reversible. ADPRibosylation, particularly if caused by a pathogen, may not be physiologically reversible.
Original comment by: jsgaravelli
noedelta
commented
12 years ago Added
Original comment by: orchard
noedelta
commented
12 years ago Original comment by: orchard
These are needed to annotate, eg PMID:21734656
Reported by: lukasz99