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HUPO-PSI / psi-mi-CV

Molecular Interactions Controll Vocabulary
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Kinetics CV #47

Closed noedelta closed 8 years ago

noedelta commented 19 years ago

Embryonic kinetics CV for your approval/comment.

Kinetics

- Binding kinetics -- Kd -- EC50

EC50 – Reaction dependent. The molar concentration of an agonist, which produces 50% of the maximum possible response for that agonist under the stated conditions. Unit M.

IC50 – Reaction dependent. The molar concentration of an agonist, which produces 50% of the maximum possible inhibitory response for that agonist under the stated conditions. Unit M.

Ki – Reaction independent. Equilibrium constant for inhibitor binding. Unit M

Km – the concentration of substrate at which the reaction rate is equal to half the maximal rate (i.e. Km={s} when V0=˝Vmax). This definition is not true for allosteric enzymes. Unit M Synonym: Michaelis-Menten constant

Kcat – the number of substrate molecules converted to product in a given unit of time on a single enzyme molecule when the enzyme is saturated with substrate. Unit. Per second Synonym: Turnover number

Kd - The equilibrium dissociation constant for a receptor/ligand, or protein A dissociating from protein B. Unit M.

Reported by: orchard

noedelta commented 18 years ago

Original comment by: luisa_montecchi