SELEX - NA-protein interaction detection

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The laboratories of G. F. Joyce, J.W. Szostak, and L. Gold independently developed a technique which allows the simultaneous screening of more than 10exp15 individual nucleic acid molecules for different functionalities. This method is commonly known as "in vitro selection", "in vitro evolution" or "SELEX" (systematic evolution of ligands by exponential enrichment). With the in vitro selection-technique large random pools of nucleic acids can be screened for a particular functionality, such as the binding to small organic molecules, large proteins or the alteration or de novo generation of ribozyme-catalysis. Functional molecules are selected from the pool of RNA or DNA by column chromatography or other selection techniques that are suitable for the enrichment of any desired property.

Reported by: jyotikhadake

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see pmid 11539574 for method decription. This method should go under paricipant detection or interaction detection?

Original comment by: luisa_montecchi

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added selex MI:0657

Original comment by: luisa_montecchi

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• status: open --> closed

Original comment by: luisa_montecchi