Add “S-CysGly” modification (monoisotopic +176.026)

HUPO-PSI / psi-mod-CV

Reactivated PSI-MOD ontology for molecular mass modifications

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Add “S-CysGly” modification (monoisotopic +176.026) #13

Closed rfellers closed 4 years ago

rfellers commented 4 years ago

In the midst of working with one of our collaborators, we ran into the need to annotate an “S-CysGly” modification (monoisotopic +176.026). My search of RESID, PSI-MOD, and Unimod turned up nothing. Paul Thomas then informed us that it is a breakdown product of S-glutathione (AA0229) and you can see evidence of its existence in manuscript form here: http://www.sciencedirect.com/science/article/pii/S1046202311002520 (Table 1). Would you be willing to add this mod?

pmt706 commented 4 years ago

Hi Ryan,

Certainly. Once the current pull request is approved, I'll get this in the queue.

Paul

ricardblum commented 4 years ago

Hi All,

It would be a good thing to add the S-CysGly (S-cysteinylglycine) modification. There are other evidences of its existence in PMID 27936627, PMID 20594348 and PMID 29627744. It is indeed a degradation product of glutathione. Glutamyl-transpeptidase cleaves glutathione into cysteinylglycine (Cys-Gly) and a Glu residue (reviewed in PMID 28537416).

Sylvie.