NTR: glutaminylated residue

[srengel]

New Term Request: glutaminylated residue

possible new child term (if appropriate): glutaminylated glutamate

reference: PMID:28801462 Jank T, et al. (2017) Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. J. Biol. Chem. 292(39):16014-16023

from the intro: "Here we describe, for the first time, a novel type of posttranslational modification, the glutaminylation of a glutamate residue, that occurs within the helix A*–loop–helix A􏰂 region of yeast eEF1A. We show that the glutamine residue is attached via its amino group to the side chain carboxyl group of Glu45 within eEF1A."

[pmt706]

MOD:02025 is (I believe) the glutaminylated glutamate that you note (references the same PMID)... although the description doesn't seem correct... thoughts @pabinz or @ricardblum (should we remove the word "free" because it's in the context of a polypeptide)? We could certainly add in the generic glutaminylated residue following that same rubric, just on the generic amino acid "X".

[Term] id: MOD:02025 name: 5-glutaminyl glutamic acid def: "A protein modification that effectively converts the alpha amino group of a glutamine residue to glutaminyl glutamic acid by forming an isopeptide bond with the side chain carboxyl group of a free glutamic acid." [PubMed:28801462] xref: DiffAvg: "128.13" xref: DiffFormula: "C 5 H 8 N 2 O 2" xref: DiffMono: "128.058576" xref: Formula: "C 10 H 15 N 3 O 5" xref: MassAvg: "257.24" xref: MassMono: "257.101167" xref: Origin: "E" xref: Source: "natural" xref: TermSpec: "none" is_a: MOD:00906 ! modified L-glutamic acid residue

[ValWood]

I agree the definition needs fixing. This is the term I requested for translation elongation factor EF-1 alpha glutamination so it should refer to a protein chain