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HUPO-PSI / psi-mod-CV

Reactivated PSI-MOD ontology for molecular mass modifications
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MOD:00312 'S-myristoyl-L-cysteine' hypothetical or natural? #73

Open nataled opened 1 year ago

nataled commented 1 year ago

PSI-MOD indicates that this modification is 'hypothetical'. However, many of the cited references--including RESID:AA0307--indicate that this is a natural residue. Can you verify and, potentially, update?

ricardblum commented 1 year ago

Hi all,

The addition of myristate to N-terminal cysteine residues (S-myristoylation) has been reported in bacteria, (see PMID 34793862 for review). S-myristoylation has also been reported in eucaryotes (/i.e/., Leishmania, PMID  10080938).

A myristate moiety bound to a cysteine residue (Cys367) has been reported in TEAD4, a transcription factor, following /in vitro/ acylation (PMID: 28960584)

I hope it helps.

Best wishes.

Sylvie.

Professor Sylvie RICARD-BLUM Pericellular and Extracellular Supramolecular Assemblies UMR 5246 CNRS - University Lyon 1 Institute of Molecular and Supramolecular Chemistry and Biochemistry University Claude Bernard Lyon 1, 43 Boulevard du 11 novembre 1918 69622 Villeurbanne Cedex, France Phone: +33(0)4 72 44 82 32 E-mail: @.***

Le 31/01/2023 à 20:38, Darren A. Natale a écrit :

PSI-MOD indicates that this modification is 'hypothetical'. However, many of the cited references--including RESID:AA0307--indicate that this is a natural residue. Can you verify and, potentially, update?

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