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HelenaLC / muscat

Multi-sample multi-group scRNA-seq analysis tools
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Muscat compared to Distinct #92

Closed chris-rands closed 2 years ago

chris-rands commented 2 years ago

What is the relationship between Muscat and Distinct (https://github.com/SimoneTiberi/distinct)? They seem to do similar things and are from the same research group? Are there recommendations on when to use which tool?

markrobinsonuzh commented 2 years ago

Hi @chris-rands

Indeed, muscat pseudobulk (PB) and distinct do similar things .. and both from us; we often have multiple ideas and in this case, they both work well. For me, PB has all kinds of other uses, like visualization .. and the results show that it works well to find differences in means, so I would say that it is the standard approach to use. If you are looking to go further, distinct should detect all the things that PB detects, but uses the full distribution and should find a "bit more" (if it's there), in terms of changes in the tails of distributions and so on. Probably, distinct has a bit higher computational cost, but it's probably not that much.

Hope that helps!

Cheers, Mark