Drug Overviews: study phase

[pubpharm]

Study phase from ChEMBL is not uptodate, especially for "older" clinical studies (information is missing in ChEMBL) --> "?" is shown, confusing the users --> lets discuss this topic

Feedback from the Roadshow Greifswald

[HermannKroll]

We should switch to Clinical Trials.gov as a data source: For instance, ClinicalTrials.gov provides information in a tabular form, e.g., https://clinicaltrials.gov/search?cond=Myocardial%20Infarct&viewType=Table&term=ROSUVASTATIN

Build a pipeline that:

• Downloads Clinical Trial data
• Extracts the tabular information
• Performs entity linking for diseases (field: condition) and drugs (field: Interventions)
• Extract all pairs of diseases and drugs plus the "highest" study phase (e.g. keep phase 4 over phase 3 if available)

The following phase options should be available:

• NA - Not Applicable -> NA
• EARLY_PHASE1 - Early Phase 1 -> I
• PHASE1 - Phase 1 -> I
• PHASE2 - Phase 2 -> II
• PHASE3 - Phase 3 -> III
• PHASE4 - Phase 4 -> IV

If no phase is available, show question mark and link to a search in clinical trials.gov

Then integrate the extracted information into the Drug Overviews. Instead of showing ChEMBL information in Drug Overviews, show information from ChEMBL. Show the highest study phase if available. When a user clicks on such a phase, forward him to a corresponding search in ClinicalTrials.gov, e.g., https://clinicaltrials.gov/search?cond=Myocardial%20Infarct&viewType=Table&term=ROSUVASTATIN

[HermannKroll]

Solved and integrated.