Looking forward to the second meeting

[andkov]

by @emielhoogendijk

Dear all,

Some information for the TC tomorrow: I have been reading the literature about cut-offs with regard to slow gait speed and weak grip strength. Most articles from the frailty field use the frailty criteria of Fried et al (2001), which includes gait speed and grip strength. Everybody copies their cut-offs, which is not completely logic as they were based on the lowest quintiles from one database, the Cardiovascular Health Study (height/sex specific for gait speed, and BMI/sex specific for grip strength, see the article in the attachment). We could follow the approach of Fried (either using their cut-offs, or derive cut-offs from lowest quintiles in our datasets) or we could go for other established measures, like a general gait speed cut-off (not taking into account sex and height).

For gait speed we can choose two approaches:

1. Use the <0.6 m/sec cut-off (see the JAMA papers of Studenski and Cummings), without any specification for sex and height.
2. Use sex and height specific cut-offs based on quintiles (derived from our own datasets, or by copying the cut-offs from Fried).

For grip strength there are no general cut-offs, as far as I know:

1. We have to decide if we use the cut-offs from Fried or the BMI & sex specific quintiles in our datasets. In many sarcopenia (see article Cruz Jentoft et al. in attachment) and frailty papers, the Fried cut-offs are being used.

I don`t know if we combine gait speed and grip strength in one paper? I would prefer to focus on gait speed first (as there is now a lot of literature about the slow gait speed as early signal of motoric problems related to starting dementia, see for example the article of Del Campo in the attachment – and also in geriatrics slow gait speed is seen as the best indicator of declining health). What would be interesting is to compare the 0.6 m/sec cut-off with the lowest quintile approach, to see whether it gives consistent results across studies. This could result in a paper that is interesting for JAGS (Journal of the American Geriatrics Society).

[andkov]

See citations with links in the ./libs/lit/README.md:

Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., ... & Topinková, E. (2010). Sarcopenia: European consensus on definition and diagnosisReport of the European Working Group on Sarcopenia in Older People. A. J. Cruz-Gentoft et al. Age and ageing, 39(4), 412-423.

Cummings, S. R., Studenski, S., & Ferrucci, L. (2014). A diagnosis of dismobility—giving mobility clinical visibility: a Mobility Working Group recommendation. Jama, 311(20), 2061-2062.

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., ... & McBurnie, M. A. (2001). Frailty in older adults: evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56(3), M146-M157.

Gobbens, R. J., van Assen, M. A., Luijkx, K. G., Wijnen-Sponselee, M. T., & Schols, J. M. (2010). Determinants of frailty. Journal of the American Medical Directors Association, 11(5), 356-364.

Studenski, S., Perera, S., Patel, K., Rosano, C., Faulkner, K., Inzitari, M., ... & Nevitt, M. (2011). Gait speed and survival in older adults. Jama, 305(1), 50-58.

Del Campo, N., Payoux, P., Djilali, A., Delrieu, J., Hoogendijk, E. O., Rolland, Y., ... & Guyonnet, S. (2016). Relationship of regional brain β-amyloid to gait speed. Neurology, 86(1), 36-43.

[andkov]

by @GracielaMuniz

There are cut off points ( height and sex specific) that can be included that would make our lives easier when considering gait speed values.

I would propose the following analytical plan: (1) separate analysis for men and women: include age, education and height & sex adjusted gait in transitions (2) repeat step (1) adding physical activity.

[andkov]

@GracielaMuniz @emielhoogendijk , the previous comment mentions physical_activity. However, my memory fails me - I do not remember us disussing it. Neither does @emielhoogendijk mentions it in issue #2

Action needed

• [ ] - Give description of physical_activity so that other drivers can see if their study has appropriate measure. (**BY EDITING ISSUE #2***)