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ICB-DCM / parPE

Parameter estimation for dynamical models using high-performance computing, batch and mini-batch optimizers, and dynamic load balancing.
MIT License
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PEtab pipeline: Only compute sensitivities with respect to optimized parameters #380

Open dweindl opened 10 months ago

dweindl commented 10 months ago

... currently this is done w.r.t. all parameters.

While less performance critical with ASA, it might still result in unnecessary simulation failures due to issues during gradient computation.

Related: #190, #343

dweindl commented 1 week ago

After #388, this will be less of an issue, since the more recent amici-petab-import will already treat petab-estimate=0 parameters as fixed parameters. What remains, is the handling of parameters w.r.t. which we only require sensitivity for certain simulation conditions. This then condition-specific amici-plist 1) needs to be written to the input files and 2) must be accounted for when aggregating the gradients from individual model simulations to the objective gradient.