Using cyrius on a specific panel of genes not WGS

Illumina / Cyrius

A tool to genotype CYP2D6 with WGS data

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Using cyrius on a specific panel of genes not WGS #20

Closed CYP2D closed 2 years ago

CYP2D commented 2 years ago

Hi, I loved the article and the accuracy. I have BAM files that contain a panel of 72 genes, i was wondering if i can use Cyrius for the CYP2D6 with these specific files or i have to use WGS BAM files. Thanks in advance, looking forward for your answer.

xiao-chen-xc commented 2 years ago

Hi @CYP2D at this point Cyrius only supports a WGS BAM. Since it assumes uniform coverage across the genome and uses some pre-defined regions in the genome for depth normalization, I wouldn't expect it to work on your panel data.