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Illumina / canvas

Canvas - Copy number variant (CNV) calling from DNA sequencing data
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Limit of detection (LOD) of canvas? #44

Closed geekgeekhello closed 6 years ago

geekgeekhello commented 7 years ago

Can Canvas be used for detecting CNVs in constitutional diseases with WES data? Basically, we expect a smaller fold change in copy number in constitutional diseases than in somatic samples. What is the Limit of Detection (LOD) of Canvas? is it able to detect a single copy of gain/loss?

chihlee commented 7 years ago

Canvas works on WES data (w/ control sample(s)). We haven't tried it on the particular type of data you described.

geekgeekhello commented 7 years ago

That's great! Thanks for the input, Steve.

On Wed, Apr 26, 2017 at 11:47 PM, Steve Lee notifications@github.com wrote:

Canvas works on WES data (w/ control sample(s)). We haven't tried it on the particular type of data you described.

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