Installing Strelka2 on macOS

[kris-nader]

Hi!

I'm trying to install Strelka 2 on my macOS but I am having some problems. I've followed the Strelka Quick start https://github.com/Illumina/strelka/blob/v2.9.x/docs/userGuide/quickStart.md but instead of version 2.9.2 I downloaded strelka-2.9.10.centos6_x86_64.tar.bz2.

The problem that I am facing is when I run: _bash strelka-2.9.10.centos6_x8664/bin/runStrelkaSomaticWorkflowDemo.bash I get the following error message: **** Starting demo configuration and run.

**** Configuration cmd: 'strelka-2.9.10.centos6_x86_64/bin/configureStrelkaSomaticWorkflow.py --tumorBam='strelka-2.9.10.centos6_x86_64/bin/../share/demo/strelka/data/NA12891_demo20.bam' --normalBam='strelka-2.9.10.centos6_x86_64/bin/../share/demo/strelka/data/NA12892_demo20.bam' --referenceFasta='strelka-2.9.10.centos6_x86_64/bin/../share/demo/strelka/data/demo20.fa' --callMemMb=1024 --exome --runDir=./strelkaSomaticDemoAnalysis'

/bin/sh: /Users/naderkri/Documents/rotation2_3/strelka-2.9.10.centos6_x86_64/libexec/htsfile: cannot execute binary file

CONFIGURATION ERROR:

Failed to pipe command: '"/Users/naderkri/Documents/rotation2_3/strelka-2.9.10.centos6_x86_64/libexec/htsfile" -h "/Users/naderkri/Documents/rotation2_3/strelka-2.9.10.centos6_x86_64/share/demo/strelka/data/NA12892_demo20.bam"'

Any ideas on how to solve this?

Best, KN