InstituteforDiseaseModeling / covasim

COVID-19 Agent-based Simulator (Covasim): a model for exploring coronavirus dynamics and interventions
https://covasim.org
MIT License
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Simulation does not account for Asymptomatic/Pre-symptomatic Spread #285

Closed bguan closed 4 years ago

bguan commented 4 years ago

Is your feature request related to a problem? Please describe.

Yes, without this feature the projection should not be used. To be effective as a tool for planning school reopening, this simulation should account for asymptomatic/pre-symptomatic spread that has been shown in newer studies to be non-negligible. Recent JAMA study shows ⅓ of subjects tested positive shows no symptom, ⅕ eventually show symptoms when in isolation. Conclusion from paper:

“Many individuals with SARS-CoV-2 infection remained asymptomatic for a prolonged period, and viral load was similar to that in symptomatic patients; therefore, isolation of infected persons should be performed regardless of symptoms.”

Describe the solution you'd like

Just like it allows for distancing effectiveness as a parameter to drive the simulation, it should allow an input for non-symptomatic contagious carrier as ratio of population, and percentage of test coverage for this group, and show the effect in the projection.

Describe alternatives you've considered

None.

Additional context

cliffckerr commented 4 years ago

This is already included in Covasim, see the symp_prob parameter. In Fig. 2 of this paper, we see 31% asymptomatic and 14% presymptomatic transmission: https://www.medrxiv.org/content/10.1101/2020.07.15.20154765v3.full.pdf image