When both are enabled together items inside chests are no longer registered as usable (they must be inside the currently selected inventory tab).
Also, the recipe scroller on the left side will completely bug out in multiple ways. These all occur when either attempting to craft an item, picking up an item, or placing an item in inventory/chest. These include:
scrolling to a random item in your currently available recipes
only allowing u to craft a single stack of an item at a time (precedes to do previous issue afterwards)
recipe scroller will disappear entirely if u click on a recipe in recipe browser
those are the issues i've found thus far