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JoRussell-IDM / emod-parasite-genetics

A collection of development and example sims for commissioning DTK sims with explicit parasite genetics
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Sporozoite Decay in the vector #2

Open JoRussell-IDM opened 3 years ago

JoRussell-IDM commented 3 years ago

Starting with knowledge that sporozoite burden in salivary glands is well measure (10^4 sporozoites).

We want to know how long these sporozoites remain viable in the vector.

  1. What is the halflife of SPZ in An. gambiae?
  2. What is the correct parameterization of a negative binomial that gives us infection probabilities that roughly match magnitude (and ideally) slope-threshold-like behavior that was described in Aleshnik et al 2020 (https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008181)
  3. Plot infection prob against SPZ load in vector
  4. How frequent are low SPZ bites?

An alternative to note for possible future behavior if it turns out that negative binomial is too restrictive on diversity bottleneck is: { genome A: 0.25 sporozoites, genome B: 0.03 sporozoites, genome C: 0.02 sporozoites } Where floats denote infection probabilities

JoRussell-IDM commented 3 years ago

Infectious vectors (~day 10 of adulthood) have on average 10^4 spz and then they remain infectious for their lifetime but spz suffer exponential decay/life expectancy model where p(t) = 1 - e^(-m*t) where m is the mortality rate, where m is 0.1.