Reference Data Aggregation

[JoRussell-IDM]

The concatenation of each reference data source containing longitudinal parasite density transitions and which dimensions of immune acquisition they may have insight on.

Ideally these are first used in isolation as ways to calibrate roughly the shape parameters governing the functional forms of immune modifiers as specified for the TM matrix.

If no longitudinal data exist, we can instead isolate the magnitude of effect on primary peak density across these same dimensions as a proxy for their relative contribution to immunity generally.

[JoRussell-IDM]

Pubmed searches

all longitudinal parasite densities ((((plasmodium) OR falciparum)) AND densit*) AND longitudinal 178 sources.

all longitudinal parasite densities with duration ((((((plasmodium) OR falciparum)) AND densit*) AND longitudinal)) AND duration 17 sources

all longitudinal parasite densities with fever ((((((fever) OR febrile) OR pyrogenic)) OR objective temperature)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 36 sources

all longitudinal parasite densities with age (((age) OR ages)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 80 sources

all longitudinal parasite densities with exposure number (((((exposure history) OR exposure number)) OR cumulative exposure)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 4 sources

all longitudinal parasite densities with recent exposure (recent exposure) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 2 sources

all longitudinal parasite densities with strain diversity ((((strain) OR antigen*) OR divers*)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 45 sources or ((((strain diversity) OR antigenic diversity) OR antigen diversity)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 4 sources

all longitudinal parasite densities with MOI ((((multiplicity) OR complexity) OR complex infection*)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 8 sources

all longitudinal parasite densities with Malaria-free interval (((since positive) OR malaria free interval)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 29 sources

all longitudinal parasite densities with first wave density ((((((peak primary) OR primary peak) OR maximum density) OR first wave density) AND parasite*)) AND (((((plasmodium) OR falciparum)) AND densit*) AND longitudinal) 10 sources

all longitudinal parasite densities with gametocytemia ((((((plasmodium) OR falciparum)) AND densit*) AND longitudinal)) AND gametocyte*) 11 sources

[JoRussell-IDM]

Features of malaria infections

Age vs. PfPR (by EIR / Season) Duration of Infection by Age (by EIR) Age vs. Clinical Incidence (by EIR / Season) EIR vs MOI (by Age) Infectiousness by Age (by EIR / Season) EIR vs. PfPR (by Age)

[JoRussell-IDM]

Duration of Infection by Age (by EIR)

Bruce et al 2000 Parasitology, PMID: 11085245 "A trend for decreasing duration with age was also noted in data from each species. This was most prominent in P. falciparum infections: median duration in 4-year-olds was > 48 days compared with a median between 9 and 15 days in older children and adults. The results are consistent with the slow acquisition of immunity to antigenically diverse Plasmodium populations and suggest a faster rate of acquisition to P. vivax and P. malariae than to P. falciparum"

[JoRussell-IDM]

Gametocyte differentiation

https://www.biorxiv.org/content/10.1101/641472v1