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JonJala / mtag

Python command line tool for Multi-Trait Analysis of GWAS (MTAG)
GNU General Public License v3.0
169 stars 54 forks source link

QTL summary statistics #137

Open anamariaUIC opened 3 years ago

anamariaUIC commented 3 years ago

Hello,

do you recommend using this software for metabolite QTL summary statistics. In my scenario I have 3 related traits I am looking into in the same cohort and doing QTL analysis on each of them. Also can you please share link to your wiki page?

Thanks Ana

JonJala commented 3 years ago

I'll have to let someone else comment on whether the method is applicable in the way you're asking, but in terms of the wiki page link, it's right here off of this repo: https://github.com/JonJala/mtag/wiki

paturley commented 3 years ago

MTAG uses LD score regression as a backbone to meta-analyze summary statistics. I'm not a metabolite QTL expert, but my understanding is that LD score regression requires GWAS summary statistics and would not work on QTL summary statistics. If I'm mistaken and QTL data works fine in LDSC, I think it should also work for MTAG.

On Mon, Jul 19, 2021 at 9:57 AM Jonathan Jala @.***> wrote:

I'll have to let someone else comment on whether the method is applicable in the way you're asking, but in terms of the wiki page link, it's right here off of this repo: https://github.com/JonJala/mtag/wiki

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