If, say, Proof of Peace was in the synthesis pool, and it needed 3 Blaze Crystals, 3 Lightning Crystals, and 3 Frost Crystals, all 9 of those crystals would exist in some format across chests and boss kills and whatever else in the randomizer, rather than being forced farm them manually. The same would go for whatever other important checks are in synthesis.
Maybe an addition to this would be to make sure these mandatory items weren't just located in synthesis too, since the intent would be to allow players to include synthesis without the farming aspect.
If, say, Proof of Peace was in the synthesis pool, and it needed 3 Blaze Crystals, 3 Lightning Crystals, and 3 Frost Crystals, all 9 of those crystals would exist in some format across chests and boss kills and whatever else in the randomizer, rather than being forced farm them manually. The same would go for whatever other important checks are in synthesis.
Maybe an addition to this would be to make sure these mandatory items weren't just located in synthesis too, since the intent would be to allow players to include synthesis without the farming aspect.