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KarchinLab / open-cravat

A modular annotation tool for genomic variants
MIT License
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gnomad update #202

Open cheanney opened 11 months ago

cheanney commented 11 months ago

Hi,

The gnomad v4 is out. Any plans on updating this source?

Thanks,

Anney

kmoad commented 10 months ago

We do plan to update to v4. It's more complicated than a typical annotator because the size of gnomad4 does not work with our model of distributing annotator data to user machines. Arguably, gnomad3 and some other full-genome annotators were already too large.

We are working on a version of gnomad that supports querying remote data sources, probably using the hail tables. Doing this performantly is driving some changes in our annotator architecture.