KlementineJBS / ELN_USYD_Honours

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Open Source Malaria Twitter Network Analysis #27

Open KlementineJBS opened 2 years ago

KlementineJBS commented 2 years ago

About

This project is looking at the Twitter networks that "talk about malaria research" and specifically those which discuss anti-malaria drug discovery. We hope to examine the place of the @O_S_M Twitter account in the anti-malarial drug discovery community, and to determine ways to improve the account's reach so that it can be used effectively to both disseminate research conducted in the open source drug discovery community and attract new collaborators.

Data Collection Protocol

Data collection began on 19-08-2021 and will be repeated on a weekly basis for an undetermined period.

NodeXL's "Twitter Search Network" function was used to search for a total of 8 terms (see: search settings). The metrics collected for each term were:

NB. An explanation of some of these terms can be found here.

Search settings

List of terms searched:

All terms except "malaria" were searched using the Twitter User Network 01 - standard worksheet option with automated graph metric calculation. The term "antibiotics" was searched using the Twitter User Network 02 - large worksheet option.

Data was collated in a Google sheet and can be accessed here. (This link allows comments only). Blank columns mean that no data was found for this search term on the date of collection.

KlementineJBS commented 2 years ago

Alteration to search terms

As of the data collected 26-8-21, better understanding of the software's capacity has led to the use of slightly different search terms, as listed below:

This reduces the number of search terms, making data collection easier, while still collecting the same data. In addition, it allows us to examine the networks of "drug discovery", "open science" and "open source" more holistically. Many tweets that contain one of these search terms will contain both the separate words and a hashtag, so collecting tweets for each iteration separately was leading to overlapping data.

KlementineJBS commented 2 years ago

Data Cleaning

Malaria AND DrugDiscovery OR Drug Discovery 08-26

Unchanged.

Malaria AND DrugDiscovery OR Drug Discovery 09-02

REMOVED (overlap with another dataset)

"Delighted to share results from our four year collaboration with @shailjasingh75, @dasgobardhan and Ram from BHU, on the discovery of drug-like molecules that modulate host NAD metabolism and combat Tuberculosis & Malaria infection. Report by @rohanduaTOI. https://t.co/0YvhkwdoAm https://t.co/7KQCuavmwg"

(47)

Malaria AND DrugDiscovery OR Drug Discovery 09-09

REMOVED (overlap with another dataset)

"Delighted to share results from our four year collaboration with @shailjasingh75, @dasgobardhan and Ram from BHU, on the discovery of drug-like molecules that modulate host NAD metabolism and combat Tuberculosis & Malaria infection. Report by @rohanduaTOI. https://t.co/0YvhkwdoAm https://t.co/7KQCuavmwg"

(11)

"@gmbutts Exploiting misinformation to score superficial moral points is exactly who Gerry is.

In 2015, Nobel Prize in HUMAN Medicine, was awarded for the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases (malaria)."

(1)

Malaria AND OpenScience OR Open Science 09-02

Unchanged. Note that tweets including "open access" and links to sciencedirect.com are gathered.

Malaria AND OpenScience OR Open Science 09-09

REMOVED (overlap with another dataset)

" "

EMPTY.

Malaria AND OpenSource AND Open Source 09-02

REMOVED:

"#Malaria parasites use #hemoglobin as a major nutrient source for its survival. Study reported several #parasite proteins in a complex involved in d process which is inhibited by drugs #chloroquine & #artemisinin. Results open windows for development of new anti-malarial #drugs. https://t.co/oX96dG1pHe"

(12)

EMPTY

Malaria AND OpenSource AND Open Source 09-09

REMOVED:

"#Malaria parasites use #hemoglobin as a major nutrient source for its survival. Study reported several #parasite proteins in a complex involved in d process which is inhibited by drugs #chloroquine & #artemisinin. Results open windows for development of new anti-malarial #drugs. https://t.co/oX96dG1pHe"

(4)

EMPTY

KlementineJBS commented 2 years ago

Malaria AND DrugDiscovery OR Drug Discovery 09-16

REMOVED (overlap with another dataset)

"Naturally acquired human #antibodies against #malaria parasites inhibits their entering red blood cells. https://t.co/8m3sO0Te94 [open access] https://t.co/VSQlPxtzS3 https://t.co/WS4Qg3Ob05"

(2)

"Delighted to share results from our four year collaboration with @shailjasingh75, @dasgobardhan and Ram from BHU, on the discovery of drug-like molecules that modulate host NAD metabolism and combat Tuberculosis & Malaria infection. Report by @rohanduaTOI. https://t.co/0YvhkwdoAm https://t.co/7KQCuavmwg"

(5)

KlementineJBS commented 2 years ago

Malaria AND DrugDiscovery OR Drug Discovery 09-23

Unchanged.

KlementineJBS commented 2 years ago

Malaria AND OpenSource OR Open Source 09-30

Unchanged.

Malaria AND OpenScience OR Open Science 09-30

Unchanged.

Malaria AND DrugDiscovery OR Drug Discovery 09-30

REMOVED (overlap with another dataset):

"Prioritization of Molecular Targets for Antimalarial Drug Discovery @DDU_Dundee @UoDLifeSciences #malaria https://t.co/WN7cdg3uIc"

(4)

"'@gmbutts Exploiting misinformation to score superficial moral points is exactly who Gerry is.

In 2015, Nobel Prize in HUMAN Medicine, was awarded for the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world’s most devastating tropical diseases (malaria)."

(3)

"Drug resistance to #malaria remains a looming threat.

To tackle the problem, new therapeutic options will be needed.

Rosanne Rotondo from @Novartis shares her thoughts on the issue and outlines how the company is working to put an end to the disease. https://t.co/IqCsY8J3Ec"

(1)

"@TrevorAHamlin @ESOR2021online Yes, it is capable of producing symmetric molecules. You would need to perform the 2nd step with the same ketone. We emphasized asymmetric compounds in this work since this class of endoperoxides is frequently employed in drug discovery, particularly for the treatment of malaria"

(2)