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KlementineJBS / USYD_PhD_ELN

This repository forms the electronic laboratory notebook (ELN)for Klementine Burrell-Sander's PhD's
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2023_BG_9C - 2-aminothiazole from 2-amino-6-fluoropyridine fragment #102

Closed KlementineJBS closed 11 months ago

KlementineJBS commented 1 year ago

KlementineJBS commented 1 year ago

Column conditions

Dryloaded using large quantity of acetone (~ 50 mL for ~0.5 g).

LRMS

Peaks at 271.00 [M-H]-, 273.11 [M+H]+ and 295.09 [M+Na]+ confirm product.

2023_BG_9C.pdf 2023_BG_9C.d.zip

KlementineJBS commented 1 year ago

NMR

1H NMR (400 MHz, DMSO-d6) δ 11.71 (s, 1H), 8.62 (ddd, J = 4.7, 1.8, 0.9 Hz, 1H), 7.98 (dt, J = 7.9, 1.2 Hz, 1H), 7.95 – 7.85 (m, 2H), 7.74 (s, 1H), 7.34 (ddd, J = 7.5, 4.8, 1.3 Hz, 1H), 7.08 (dd, J = 8.0, 2.1 Hz, 1H), 6.67 (dd, J = 7.8, 2.1 Hz, 1H).

19F NMR (376 MHz, DMSO) δ -70.72.

13C NMR (101 MHz, DMSO) δ 162.61, 160.25, 159.57, 152.21, 151.12, 150.96, 149.44, 149.13, 143.03, 142.94, 137.17, 122.63, 119.90, 110.06, 107.54, 107.50, 99.18, 98.83.

2023_BG_9C 400 MHz.pdf 230623_9C_1.zip 230623_9C_2.zip 230623_9C_3.zip

KlementineJBS commented 1 year ago

Melting point

Range of 202 - 220 C.

9C is centre (red)

KlementineJBS commented 1 year ago

IR

2023_BG_9C (1).pdf