search

KlementineJBS / USYD_PhD_ELN

This repository forms the electronic laboratory notebook (ELN)for Klementine Burrell-Sander's PhD's
2 stars 0 forks source link

2023_BG_10C - 2-aminothiazole from 2-amino-5-fluoropyridine fragment #103

Closed KlementineJBS closed 11 months ago

KlementineJBS commented 1 year ago

image

KlementineJBS commented 1 year ago

Column conditions

Dissolved in DCM and MeOH.

LRMS

Peaks at 271.03 [M-H]-, 273.05 [M+H]+ and 295.11 [M+Na]+ confirm product.

2023_BG_10C.d.zip 2023_BG_10C.pdf

KlementineJBS commented 1 year ago

NMR

1H NMR (400 MHz, DMSO-d6) δ 11.51 (s, 1H), 8.61 (ddd, J = 4.7, 1.8, 0.9 Hz, 1H), 8.33 (d, J = 3.0 Hz, 1H), 7.98 (dt, J = 7.9, 1.2 Hz, 1H), 7.89 (td, J = 7.7, 1.8 Hz, 1H), 7.74 (ddd, J = 9.2, 8.4, 3.0 Hz, 1H), 7.65 (s, 1H), 7.33 (ddd, J = 7.4, 4.8, 1.3 Hz, 1H), 7.20 (ddd, J = 9.0, 3.8, 0.6 Hz, 1H).

19F NMR (376 MHz, DMSO) δ -138.48.

13C NMR (101 MHz, DMSO) δ 159.99, 155.55, 153.12, 152.37, 149.40, 148.99, 148.63, 137.12, 133.16, 132.91, 126.38, 126.17, 122.52, 119.86, 111.96, 108.98.

230623_10C_1.zip 230623_10C_2.zip 230623_10C_3.zip

2023_BG_10C 400 MHz.pdf

KlementineJBS commented 1 year ago

Melting point

Range of 198 - 207 C.

10C is right (green)

KlementineJBS commented 1 year ago

IR

2023_BG_10C.0.zip 2023_BG_10C (1).pdf