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KlementineJBS / USYD_PhD_ELN

This repository forms the electronic laboratory notebook (ELN)for Klementine Burrell-Sander's PhD's
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2023_BG_8C - 2-aminothiazole from 2-amino-5-methoxypyridine fragment #105

Closed KlementineJBS closed 9 months ago

KlementineJBS commented 1 year ago

2023_BG_8C full scheme

KlementineJBS commented 1 year ago

Column conditions

Dryloaded using acetone

KlementineJBS commented 1 year ago

LRMS

Peaks at 283.09 [M-H]-, 285.14 [M+H]+ and 307.12 [M+Na]+ confirm presence of product.

2023_BG_8C.pdf 2023_BG_8C.d.zip

Note that file name in .zip folder is incorrect.

KlementineJBS commented 1 year ago

NMR

1H NMR (400 MHz, DMSO-d6) δ 11.24 (s, 1H), 8.59 (ddd, J = 4.7, 1.8, 0.9 Hz, 1H), 8.05 (dd, J = 3.0, 0.7 Hz, 1H), 7.96 (dt, J = 7.9, 1.2 Hz, 1H), 7.87 (td, J = 7.7, 1.8 Hz, 1H), 7.58 (s, 1H), 7.45 (dd, J = 9.0, 3.0 Hz, 1H), 7.31 (ddd, J = 7.4, 4.8, 1.3 Hz, 1H), 7.11 (dd, J = 9.0, 0.7 Hz, 1H), 3.81 (s, 3H).

13C NMR (101 MHz, DMSO) δ 160.29, 152.50, 150.25, 149.37, 148.89, 146.09, 137.08, 131.24, 125.85, 122.43, 119.83, 111.45, 108.41, 55.96.

2023_BG_8C 400 MHz.pdf 230623_8C_1.zip 230623_8C_2.zip

KlementineJBS commented 1 year ago

Melting point

Range of 204 - 212 C.

8C is left (white)