2023_BG_1C - 2-aminothiazole from 2-fluoroaniline fragment

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Column conditions

Dissolved in DCM.

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H NMR

Determined that fractions 6-10 and 11-18 contained desired product.

2023_BG_1C F1-3_1.zip 2023_BG_1C F6-10_1.zip 2023_BG_1C F11-18_1.zip 2023_BG_1C F19-21_1.zip

2023_BG_1C 300 MHz.pdf

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LRMS

Peaks at 272.13 [M+H]+ and 294.10 [M+Na]+ confirm presence of product.

2023_BG_1C.pdf 2023_BG_1C.d.zip

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IR

3232, 3121, 3056, 3012, 1620, 1541, 1486, 1288, 1253

2023_BG_1C.0.zip 2023_BG_1C (1).pdf

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NMR

1H NMR (400 MHz, Chloroform-d) δ 8.54 (ddd, J = 4.9, 1.9, 0.9 Hz, 1H), 8.13 (td, J = 8.3, 1.6 Hz, 1H), 7.99 (dt, J = 7.9, 1.1 Hz, 1H), 7.73 (td, J = 7.7, 1.8 Hz, 1H), 7.51 (s, 1H), 7.20 – 7.08 (m, 2H), 7.06 (ddd, J = 11.3, 8.2, 1.5 Hz, 1H), 6.99 – 6.88 (m, 1H).

13C NMR (101 MHz, CDCl3) δ 163.16, 153.14, 152.17, 150.80, 150.73, 149.00, 137.34, 128.85, 128.75, 124.74, 124.70, 122.66, 122.65, 122.59, 121.23, 118.49, 115.21, 115.02, 107.67, 77.32, 77.00, 76.69.

20230702_1C_1.zip 20230702_1C_2.zip 2023_BG_1C 400 MHz.pdf

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2023_BG_1C

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after purification