2023_SSP_8C - Purification of student-synthesised material

[KlementineJBS]

Reaction scheme

[KlementineJBS]

LRMS

303.15, 305.14 [M+H]+, 325.05 [M+Na]+, 301.02 [M-H]-. (Chlorine isotopes visible in M+H ionisation.)

2023_SSP_8C.pdf 2023_SSP_8C.d.zip

[KlementineJBS]

HPLC

Purity = 74.29%

[KlementineJBS]

Column

Columned 380 mg crude material.

Used neutral alumina as this showed best results on TLC. However, according to both TLC and the isolera's UV detector, only one species seemed to come off. Flushed with ~100 mL of 50:50 EtOAc:hexane and ~200 mL of 100% EtOAc, but these also seemed to contain the same spot according to TLC.

[KlementineJBS]

LRMS

2023_SSP_8C flasks.d.zip 2023_SSP_8C flasks.pdf

[KlementineJBS]

HPLC