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KlementineJBS / USYD_PhD_ELN

This repository forms the electronic laboratory notebook (ELN)for Klementine Burrell-Sander's PhD's
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2023_BG_9B_1 - Hydrolysis on 2-amino-6-fluoropyridine fragment #86

Closed KlementineJBS closed 1 year ago

KlementineJBS commented 1 year ago

Reaction scheme

2023_BG_9B

Outcome

403.3 mg (2.36 mmol, 81%)

KlementineJBS commented 1 year ago
  1. Dissolved SM (804 mg, 2.92 mmol) in NaOH (2.5 M, 5 mL)
  2. Stirred at 80 C from 2.25 pm

TLC at 2.55 pm indicated completion.

Work up as usual - see step 2.

KlementineJBS commented 1 year ago

Vial empty: 15.6081 Vial full: 16.0114 Mass: 403.3 mg (2.36 mmol, 81%)

KlementineJBS commented 1 year ago

NMR

1H NMR (300 MHz, DMSO-d6) δ 10.77 (s, 1H), 9.55 (s, 1H), 8.99 (s, 1H), 7.95 (q, J = 8.2 Hz, 1H), 7.14 (dd, J = 8.1, 1.9 Hz, 1H), 6.81 (dd, J = 8.0, 2.0 Hz, 1H).

2023_BG_9B_1_1 (1).zip 2023_BG_9B_2.pdf

13C NMR (126 MHz, DMSO) δ 180.86, 161.84, 159.94, 151.95 (d), 144.39 (t), 109.96 (d), 102.16 (d).

230709_9B_2 (1).zip 2023_BG_9B 500 MHz.pdf