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KlementineJBS / USYD_PhD_ELN

This repository forms the electronic laboratory notebook (ELN)for Klementine Burrell-Sander's PhD's
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2023_BG_10B_2 - Hydrolysis on 2-amino-5-fluoropyridine fragment #96

Closed KlementineJBS closed 1 year ago

KlementineJBS commented 1 year ago

Reaction scheme

2023_BG_10B

Outcome

KlementineJBS commented 1 year ago
  1. Dissolved SM (12.1549 g, 44.2 mmol) in NaOH (2.5 M, 40 mL)
  2. Heated from 4.15 pm

TLC indicated completion at ~ 5.15 pm.

Work up as usual - see step 2.

KlementineJBS commented 1 year ago

LRMS

Peak at 170.05 [M-H]-. Oddly - peak at 194.03 (+4) would be expected to correspond to [M+Na]+ but should only have a +1 charge.

2023_BG_10B_2.pdf 2023_BG_10B_2.d.zip

KlementineJBS commented 1 year ago

Vial 1: 15.9477 Full vial: 20.7765 Mass: 4.8288

Vial 2: 15.7181 Full vial: 19.1645 Mass: 3.4464

Total mass = 8.2752 g (48.3 mmol, over 100%)

KlementineJBS commented 1 year ago

H NMR

Matches with spectrum of #85

2023_BG_10B_2_1.zip 2023_BG_10B_2.pdf