Knowledge-Graph-Hub / kg-idg

A Knowledge Graph to Illuminate the Druggable Genome
https://knowledge-graph-hub.github.io/kg-idg/
BSD 3-Clause "New" or "Revised" License
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Add ingest for drug indications from DrugCentral #115

Closed caufieldjh closed 1 year ago

caufieldjh commented 2 years ago

The omop_relationships table looks like this:

id      struct_id       concept_id      relationship_name       concept_name    umls_cui        snomed_full_name        cui_semantic_type       snomed_conceptid
174026  5391    40249429        indication      Triple negative breast neoplasms        C3539878        Triple negative breast neoplasms        T191    706970001
174027  5392    40249397        indication      Metastatic non-small cell lung cancer   C0278987        Metastatic non-small cell lung cancer   T191
174028  5393    40249397        indication      Metastatic non-small cell lung cancer   C0278987        Metastatic non-small cell lung cancer   T191
174029  5393    40248953        indication      Medullary thyroid carcinoma     C0238462        Medullary thyroid carcinoma     T191    255032005
174030  5394    21004733        indication      Gastrointestinal stromal tumor  C0238198        Gastrointestinal stromal tumor  T191    420120006
174031  5395    40249050        indication      Positron emission tomography    C0032743        Positron emission tomography    T060    82918005
174032  5396    40249050        indication      Positron emission tomography    C0032743        Positron emission tomography    T060    82918005
174033  5397    40249391        indication      Neuromyelitis optica    C0027873        Neuromyelitis optica    T047    25044007
174034  5397    21013561        contraindication        Viral hepatitis type B  C0019163        Viral hepatitis type B  T047    66071002
174035  5397    21000041        contraindication        Tuberculosis    C0041296        Tuberculosis    T047    56717001
174036  5398    21000522        indication      Small cell carcinoma of lung    C0149925        Small cell carcinoma of lung    T191    254632001
174037  5400    21003038        indication      Sedation        C0344106        Sedation        T061    72641008
174038  5402    21002917        indication      Myelodysplastic syndrome        C0026986        Myelodysplastic syndrome        T191    109995007
174039  5402    40249380        indication      Chronic myelomonocytic leukemia C0023480        Chronic myelomonocytic leukemia T191    127225006
174040  5403    21000399        indication      Pediculosis capitis     C0030757        Pediculosis capitis     T047    81000006
174041  5404    40249359        indication      Diffuse large B-cell lymphoma refractory        C0855112        Diffuse large B-cell lymphoma refractory        T191
174042  5405    40249370        indication      Relapse multiple myeloma        C2349261        Relapse multiple myeloma        T191
174043  5406    21003084        indication      Severe pain     C0278140        Severe pain     T184    76948002
174044  5406    40249290        indication      Moderate pain   C0278139        Moderate pain   T184    50415004
caufieldjh commented 2 years ago

Would like to map the UMLS CUIs or SNOMED IDs to MONDO or HPO. For MONDO, there are already skos:exactMatch relations to provide the xrefs

caufieldjh commented 2 years ago

In HPO they (UMLS CUIs, at least) aren't in the KG-OBO graph but are in the OWL as hasDbXrefs

Use the xrefs!

caufieldjh commented 1 year ago

Remaining: