Additional value ingests from DrugCentral

Knowledge-Graph-Hub / kg-idg

A Knowledge Graph to Illuminate the Druggable Genome

https://knowledge-graph-hub.github.io/kg-idg/

BSD 3-Clause "New" or "Revised" License

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Additional value ingests from DrugCentral #44

Closed caufieldjh closed 2 years ago

caufieldjh commented 2 years ago

As per discussion with Tudor, Jeremy et al. on Nov 11 IDG call: Should verify that the following are being ingested:

Strength values for drug-target interactions (note these are log scale, and should not be used for any kind of quality filter without also comparing to TDL membership for the target)
INN drug classification by name (primarily for assigning function / mode of action)

caufieldjh commented 2 years ago

Currently using the bioactivity measurement values (IC50, etc) from DrugCentral for this, but should add the values from TCRD

caufieldjh commented 2 years ago

Unclear where the drug to INN mappings are in the DrugCentral DB - there's a table inn_stem but that just defines the INN categories.

caufieldjh commented 2 years ago

Jeremy Yang suggests to use the identifier table to retrieve INN_IDs. There are a variety of other identifier types in there, too.

caufieldjh commented 2 years ago

Have a commit to transform the DrugCentral identifier table (8f6220e71af92e00763b384ca3e42f99e0dcf08c) and ideally these would all be stored as xrefs on each drug, but Biolink doesn't allow the xref slot on Drug at the moment. Alternative is to treat as attribute.