Expansion upon Median Unifrac to compute average phylogenetic distances between samples according to their UniFrac distance without producing negative abundance vectors.
Start big: what UniFrac is, how it is used
Begin to focus in: recent developments (StripedUnifrac, EMDUniFrac, DPCoA papers that Jason cites)
Detail the problem: with huge data sets, is computationally burdensome to compute all pairwise distances
Present the solution: L2UniFrac and means
Start big: what UniFrac is, how it is used Begin to focus in: recent developments (StripedUnifrac, EMDUniFrac, DPCoA papers that Jason cites) Detail the problem: with huge data sets, is computationally burdensome to compute all pairwise distances Present the solution: L2UniFrac and means