Kurt-Hetrick / CIDR_SOMATIC_WES_PIPELINES

currently for paired tumor - normal WES samples processed with TWIST UMIs
MIT License
1 stars 0 forks source link

combine germline calls with somatic calls #14

Open Kurt-Hetrick opened 1 year ago

Kurt-Hetrick commented 1 year ago

so i don't forget this. there is utility for this, i.e. if you are looking for compound heterozygote that arises due to a somatic variant...the complicating factor is that for this pipeline, no calls are from joint calling so results are sub optimal...one could conceivably joint call normals and combine somatic calls with normals, but this does not scale well because extraction of per sample normal calls from joint called vcf can be a time consuming process depending on vcf size, but having a version is better than no version, i guess.