Kurt-Hetrick / CIDR_SOMATIC_WES_PIPELINES

currently for paired tumor - normal WES samples processed with TWIST UMIs
MIT License
1 stars 0 forks source link

compare umi-aware dup pipeline to idt pipeline #5

Open Kurt-Hetrick opened 1 year ago

Kurt-Hetrick commented 1 year ago

On the surface, I really don't see the need to do most of what IDT does in their pipeline. There shouldn't be a need to run bwa the way that they do and the whole "consensus, grouping workflow plus variant caller of choice" should be analogous to umi-aware dup marking plus haplotype caller gvcf (or mutect2) generation. but will probably have to perform side by side test to see if one performs better than the other.