Why are you using a picture box for a "game"? Learn how to draw using DX11/12 or at least OGL.
VB.NET, seriously? Move away from a deprecated language and learn C# or C++
The code is a legit pasta (but that's to be expected from a guy that can't even keep his 2b2t clone running). Learn coding Nate.
If-if-if-if-if, do you have a if-addiction? Because if you had any common sense, you would be able to make this garbage without 50 trillion if-statements,
Memory usage, do you know what that is? If you do, respect it and then look at your code and how it performs 🤦♂️