LieberInstitute / Visium_SPG_AD

Visium SPG AD project (n = 10) using Visium Spatial Proteogenomics (Visium-SPG) on dissections from the inferior temporal cortex (ITC) from Alzheimer's disease cases and controls.
https://research.libd.org/Visium_SPG_AD
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Check FDR thresholds for the enrichment t-stats #63

Closed lcolladotor closed 1 year ago

lcolladotor commented 2 years ago

Note that right now 2,691 genes pass the filterByExpr() in TGE and 8,443 pass that in WG. So I think that maybe the FDR 5% mark might be at a higher p-value in TGE than what we see in WG. But we haven’t checked this.

Make a table with 14 rows (7 x 2) and 4 columns. The 7 rows will be the 7 pathology categories, x 2 for TGE and WG. The columns will be: type (WG or TGE), pathology category (7 options) pvalue, and FDR.

Then the cells for the pvalue column will be the max p-value to FDR 5% for the enrichment t-stats. The FDR one will be the actual FDR.

I suspect that some rows will have NAs since we don't have FDRs close to 5% in many of the enrichment t-stat tests.

The inputs will be: