Visium SPG AD project (n = 10) using Visium Spatial Proteogenomics (Visium-SPG) on dissections from the inferior temporal cortex (ITC) from Alzheimer's disease cases and controls.
Note that right now 2,691 genes pass the filterByExpr() in TGE and 8,443 pass that in WG. So I think that maybe the FDR 5% mark might be at a higher p-value in TGE than what we see in WG. But we haven’t checked this.
Make a table with 14 rows (7 x 2) and 4 columns. The 7 rows will be the 7 pathology categories, x 2 for TGE and WG. The columns will be: type (WG or TGE), pathology category (7 options) pvalue, and FDR.
Then the cells for the pvalue column will be the max p-value to FDR 5% for the enrichment t-stats. The FDR one will be the actual FDR.
I suspect that some rows will have NAs since we don't have FDRs close to 5% in many of the enrichment t-stat tests.
Make a table with 14 rows (7 x 2) and 4 columns. The 7 rows will be the 7 pathology categories, x 2 for TGE and WG. The columns will be:
type
(WG or TGE),pathology
category (7 options)pvalue
, andFDR
.Then the cells for the
pvalue
column will be the max p-value to FDR 5% for the enrichment t-stats. TheFDR
one will be the actual FDR.I suspect that some rows will have NAs since we don't have FDRs close to 5% in many of the enrichment t-stat tests.
The inputs will be: