From https://lemire.me/blog/
In a small clinical trial, scientists administered some “anti-aging” therapies to people between their fifties and sixties. They used growth hormone to regenerate the thymus, part of our immune system which is nearly all gone when people reach 50 years old. They complemented this therapy with anti-diabetes drugs (dehydroepiandrosterone and metformin) as an attempt to compensate for the fact that growth hormone is pro-diabetic. The researchers found that in a majority of the participants, the thymus was indeed regenerated: to my knowledge, this is a breakthrough in human beings (we only knew that in worked in animal models). Further, using an epigenetic clock, they found that participants’ biological age was reversed, by 2.5 years on average. The result persisted six months after stopping the trial. The surprising results should be viewed with caution given that it was a small trial with no control. Nevertheless, to my knowledge, it is the first time that biological aging has been reversed in human beings following a supervised therapy. The article is short and readable. (Source: Nature)
From https://lemire.me/blog/ In a small clinical trial, scientists administered some “anti-aging” therapies to people between their fifties and sixties. They used growth hormone to regenerate the thymus, part of our immune system which is nearly all gone when people reach 50 years old. They complemented this therapy with anti-diabetes drugs (dehydroepiandrosterone and metformin) as an attempt to compensate for the fact that growth hormone is pro-diabetic. The researchers found that in a majority of the participants, the thymus was indeed regenerated: to my knowledge, this is a breakthrough in human beings (we only knew that in worked in animal models). Further, using an epigenetic clock, they found that participants’ biological age was reversed, by 2.5 years on average. The result persisted six months after stopping the trial. The surprising results should be viewed with caution given that it was a small trial with no control. Nevertheless, to my knowledge, it is the first time that biological aging has been reversed in human beings following a supervised therapy. The article is short and readable. (Source: Nature)