Closed SourceForge-exporter closed 9 years ago
Surely this is something that happens as a result of an interaction, not the state of the participant during the interaction. With ptms we only describe as features, the PTMs required for the interaction to occur, not those which occur as the result of a phosphorylation, or acetylation but we do have the term 'resultant-ptm' as a feature attribute. I could add resultant-cleavage as a child of that.
Original comment by: orchard
The UniProt annotation rules for cleavage site features should be followed. Cleavage site features have a "range" that is the canonical sequence locations of the adjacent amino acids forming the peptide bond being broken.
Original comment by: jsgaravelli
MI:1223
Original comment by: orchard
Original comment by: orchard
This would be a direct child of the biological feature used to specify position of the peptide bond cleaved by a protease See, eg, PMID:20439754 If the term is accepted we should probably also add a note in the cv/curation manual(s) to ensure consistent region annotation - one possibility is to specify something like 102-103 range if the peptide bond between residues 102 and 103 is cut. Specifying consistently just one residue might be a viable option.
Reported by: lukasz99