MRCIEU / opengwas-requests

A place to request or contribute data to the IEU GWAS database
3 stars 0 forks source link

Various issues with GWAS in the database #21

Open marynias opened 2 years ago

marynias commented 2 years ago

Wrong data (beta/SE) - massively inflated values (leads to all my MR analyses turning significant!) for these breast cancer and asthma GWAS:

ebi-a-GCST007799 ebi-a-GCST007800 ebi-a-GCST007236

Same as above plus negative SE in that GWAS: ebi-a-GCST006980

OpenGWAS website states that these FinnGen GWAS coordinates are GRCh37, however, the coordinates are actually for GRCh38 (likely applies to other FinnGen GWAS): finn-a-BIGUANIDES finn-a-ANY_CANC finn-a-CD2_BENIGN_LEIOMYOMA_UTERI finn-a-E4_DM2 finn-a-E4_HYTHYNAS finn-a-H7_CATARACTSENILE finn-a-H7_IRIDOCYCLITIS finn-a-I9_HYPTENS finn-a-I9_VARICVE finn-a-II_NEOPLASM finn-a-K11_CHOLELITH finn-a-K11_HERNIA finn-a-SPONDYLOARTHRITIS

These BBJ GWAS I had a look at don't have RSID as identifiers but positional identifiers (in the form of 1_904165_G_A) instead. I only focused on these but I noticed that there is no consistency - other BBJ GWAS do have RSIDs as identifiers, as expected. bbj-a-107 bbj-a-119 bbj-a-105